Cardiovascular Research and Clinical Trials
Your neighbors, co-workers and friends – people you see every day may be “medical heroes”. By participating in clinical research trials, volunteers help to further advancements in medical therapy and technologies for a variety of health care diseases. Every medication that is prescribed to you by your physician has undergone rigorous testing through clinical trials prior to FDA approval. Without this testing, life-saving effects could not be made available to the general public. MyMichigan Health is a part of that process in the Clinical Research Department.
MyMichigan physicians have developed an international reputation for their research activities. Currently all of the Cardiovascular Physicians, Interventionists, Electrophysiologists, Physicians Assistants and Nurse Practitioners in the Cardiovascular Specialty are actively participating in screening for and monitoring the care of research participants.
Registered Nurse Research Coordinators screen Cardiologists' patients for individuals who meet specific criteria for studies and then collaborate with patients and physicians for enrollment.
The Clinical Research Department conducts Phase II, III, and IV studies. Most are outcome studies, meaning the trials involve testing drugs and treatments on larger groups of volunteers after a safe dosage and initial side effects have been identified. Patients are regularly monitored, and data is collected that helps determine the effectiveness and safety of a treatment, including any different impacts across gender and race. Through the process, which is of no cost to volunteers, patients receive frequent medical care related to the clinical trial. They often develop relationships with MyMichigan Health staff that last beyond their volunteer experience. Misconceptions about clinical research trials are common. Volunteering is often portrayed negatively in television medical dramas and other media, leading to concerns about safety and necessity of the research. We follow rigorous patient screening and safety measures. The MyMichigan Health institutional Review Board also oversees all aspects of research done locally.
As “medical heroes” throughout the Great Lakes Bay Region, MyMichigan Health continues to participate in clinical research trials and remains a valuable resource in the fight against heart disease and the advancement of cardiovascular treatments.
MyMichigan Cardiovascular Current Clinical Trials
Cardiac Catheterization/Stent trials/Cardiac Surgery/CRT-pacing Trials
- ENVISION - Dr. Ali
ENVISION IDE Trial: Safety and Effectiveness of NAVITOR in Transcatheter Aortic Valve Implantation
- REN-007 & REN-007E - Dr. Felten
- REN-007
- REN-007E
- An Evaluation of Patient Reported Outcomes and Clinical Outcomes
- Enrollment contingent on participation in REN-007
- NCT: 06092970
Cardiovascular Disease Trials
- REMBRANDT - Dr. Doghmi
A CCTA Imaging Trial to Evaluate the Effect of Obicetrapib/Ezetimibe on Coronary Plaque (REMBRANDT)
- Victorion 1 Prevent - Dr. Doghmi
A randomized, double-blind, placebo-controlled, multicenter study to evaluate the effect of inclisiran on preventing major adverse cardiovascular events in high-risk primary prevention patients.
Heart Attack/Myocardial Infarction
- ARTEMIS - Dr. Mattichak
A Research Study to Look at How Ziltivekimab Works Compared to Placebo in People With a Heart Attack (ARTEMIS)
- Dal-GenE-2- Dr. Felton
Effect of Dalcetrapib on CV Risk in a Genetically Defined Population With a Recent ACS (dal-GenE-2)
- SOS-AMI - Dr. Doghmi
Multi-center, Double-blind, Randomized, Placebo-controlled, Parallel-group Study to Evaluate the Efficacy and Safety of Self-administered Subcutaneous Selatogrel for Prevention of All-cause Death and Treatment of Acute Myocardial Infarction in Subjects With a Recent History of Acute Myocardial Infarction.
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VICTORION (V2P) - Dr. Boguszewski
A Randomized, Multicenter, Open-label Trial Comparing the Effectiveness of an "Inclisiran First" Implementation Strategy to Usual Care on LDL Cholesterol (LDL-C) in Patients With Atherosclerotic Cardiovascular Disease and Elevated LDL-C (≥70 mg/dL) Despite Receiving Maximally Tolerated Statin Therapy (VICTORION-INITIATE)
Heart Failure Trials
- DAPA-ACT HF - Dr. Boguszewski
Brigham and Women's Hospital/TIMI Study Group: A multicenter, randomized, double-blind, parallel group, placebo-controlled trial to evaluate the effect of in-hospital initiation of dapagliflozin on clinical outcomes in patients with heart failure with reduced ejection fraction who have been stabilized during hospitalization for acute heart failure.
Peripheral Artery Disease Trial
- Chocolate Touch - Dr. Constantinou
A randomized trial to confirm the safety and effectiveness of Chocolate Touch ™ Paclitaxel coated balloon catheter, in above the knee lesions.
- Patients in follow-up only
- NCT: 02924857
New clinical trials are available often. Please contact the Clinical Research Department at (989) 631-2469 or by email at cvresearch@mymichigan.org for more details.
